Toll Like Receptor 4 Expression Profile in Mice Infected Mycobacterium Tuberculosis Given with Miana Leaves Extract (Coleus scutellarioides (L.) Benth) (Tuberculosis Preventive and Curative Mechanisms)

Introduction: Tuberculosis is an infectious disease of the respiratory tract caused by Mycobacterium tuberculosis. During tuberculosis infection, pathogens modulate TLR-4 receptor flow signaling, suggesting possible involvement in regulation host immune response. This study aims to determine effect miana leaf extract on expression toll like 4 (TLR-4) mice at preventive and curative stages. Methods: Mice were divided into 3 groups with 7x replication. Providing 14 days treatment, incubation treatment. Group 1 group given Miana Leaves Extract (EDM) placebo all three 2 was EDM stages, then they anti-tuberculosis drugs (OAT). Results: The results proved that as a did not increase protein healthy mice; Changes M.tb-infected before after increased 17%, administration 97% decreased 12% OAT administration; 20%, 102% 10% OAT. Conclusions: has potential antituberculosis regulatory mechanism.